GCMS – Bile Acids

GCMS – Bile Acids

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Current immunoassays for Bile acids measure the total bile acids present. Monitoring each of the individual major bile acids will enable the significant biases and differences observed between each of the methods to be addressed

Traceability - Serum/Plasma

Analyte Standard (certfied purity)Control Material
Cholic AcidSigma >99%"In house"
Deoxycholic AcidSigma >99%"In house"
Chenodeoxycholic AcidSigma >99%"In house"

Analytical Method Details

Analyte / Internal Standard Sample pre-treatmentDerivative

Cholic Acid
[2,2,4,4,-d4] cholic acid

Solid phase extraction
Gel Chromatography
Silyl methyl ether
Deoxycholic acid
[2,2,4,4,-d4]-deoxycholic acid
Solid phase extraction
Gel Chromatography
Silyl methyl ether
Chenodeoxycholic acid
[2,2,4,4,-d4]-chenodeoxycholic acid
Solid phase extraction
Gel Chromatography
Silyl methyl ether

Accreditation

UKAS Proficiency Testing 4301UKAS Calibration 4301


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